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PNC-28
Also known as: p53-derived peptide (residues 17-26 + PTD)
Synthetic peptide fragment derived from the p53 tumor-suppressor protein.
PNC-28 is a synthetic peptide comprising residues 17–26 of the p53 transactivation domain fused to a membrane-residency signal from the penetratin class.
It was developed as a research tool to study p53-independent induction of apoptosis in transformed cell lines.In cancer cell-line research, PNC-28 has been studied for its proposed interaction with HDM-2 (the p53 regulator) and for inducing membrane-mediated cell death pathways.
Published investigations have explored its activity against several tumor cell lines in vitro and in xenograft models.PNC-28 is primarily of interest in oncology-adjacent research settings and is cataloged for specialist laboratory use.
Research applications
- p53 signaling pathway research
- HDM-2/MDM-2 interaction studies
- Apoptosis and programmed cell-death mechanisms
- Cancer cell-line in-vitro research
- Membrane-active peptide biology
Technical profile
- Net content
- 20 mg
- Molecular formula
- C164H255N47O37S
- Molecular weight
- 3509.13 g/mol
- CAS
- 392661-17-5
- Sequence
- Glu-Thr-Phe-Ser-Asp-Leu-Trp-Lys-Leu-Leu-Lys-Lys-Trp-Lys-Met-Arg-Arg-Asn-Gln-Phe-Trp-Val-Lys-Val-Gln-Arg-Gly
For research use only. Not for human or veterinary consumption. Not intended to diagnose, treat, cure, or prevent any disease. Catalog availability restricted to verified licensed practitioners.
PNC-28 is a p53-derived peptide targeting the HDM-2 binding site on cancer cells. Research demonstrates it selectively induces necrosis in cancer cells expressing mutant p53 while leaving normal cells unaffected, making it a novel oncology research tool.
