Healing & Tissue RepairIn StockHealing & Tissue Repair
ARA-290
Also known as: Cibinetide
Synthetic 11-amino-acid peptide derived from the helix-B domain of erythropoietin.
ARA-290 (cibinetide) is a synthetic peptide designed to mimic a region of the erythropoietin (EPO) molecule — specifically the helix-B domain — that interacts with the innate repair receptor (IRR) complex, comprising the EPO receptor and the common beta-subunit (CD131).Unlike full-length EPO, ARA-290 lacks erythropoietic activity, which has made it a useful research tool for isolating non-hematopoietic signaling functions of the EPO-like pathway.
Published investigations have examined ARA-290 in models of neuropathy, metabolic-inflammatory states, and tissue-protective signaling.This compound has advanced into early-phase clinical trials for specific indications and is referenced in ongoing research on the innate repair receptor mechanism.
Research applications
- Innate repair receptor (IRR) signaling pathway research
- Neurovascular and peripheral neuropathy models
- Anti-inflammatory cytokine pathway studies
- Metabolic-tissue research (including sarcoidosis models)
- Tissue-protection signaling independent of erythropoiesis
Technical profile
- Net content
- 14 mg
- Molecular formula
- C55H85N17O16
- Molecular weight
- 1256.38 g/mol
- CAS
- 1208243-50-8
- Sequence
- Pyr-Glu-Gln-Leu-Glu-Arg-Ala-Leu-Asn-Ser-Ser
For research use only. Not for human or veterinary consumption. Not intended to diagnose, treat, cure, or prevent any disease. Catalog availability restricted to verified licensed practitioners.
ARA-290 is an 11-amino-acid peptide that selectively activates the innate repair receptor (IRR), a heteromer of the erythropoietin and beta-common receptors. It promotes tissue repair and exhibits anti-inflammatory and neuroprotective properties without erythropoietic effects.
