Metabolic & Weight ManagementIn StockMetabolic & Weight Management
AOD-9604
Also known as: Anti-Obesity Drug 9604, hGH 177-191 analog, Tyr-hGH(177-191)
Synthetic 16-amino-acid analog of the C-terminal fragment of human growth hormone (hGH 177-191), modified with an N-terminal tyrosine residue.
AOD 9604 is a synthetic peptide corresponding to the C-terminal 177-191 region of the human growth hormone (hGH) molecule, extended at the N-terminus with a single tyrosine residue to improve stability and analytical tractability. The parent fragment was investigated in the 1990s and early 2000s at Monash University (Australia) and subsequently advanced into clinical investigation by Metabolic Pharmaceuticals.
The published research literature on AOD 9604 is narrower than that of most peptides in the Novera catalog and is concentrated in two areas. The first is lipolytic signaling: preclinical and Phase 2b clinical investigations examined its effects on adipose-tissue metabolism independent of classical growth-hormone-receptor activity. The second is cartilage and joint-tissue biology, where AOD 9604 has been explored in preclinical osteoarthritis models as a candidate for chondroprotective research.
AOD 9604 does not bind the classical GH receptor in the manner of full-length hGH; its mechanism remains incompletely characterized in the primary literature. It is included in the Novera catalog as a reference research compound for investigators working in adipose-tissue metabolism and connective-tissue biology. Supplied as a lyophilized powder for in-vitro laboratory research applications only.
Research applications
- Adipose-tissue lipolysis and fat-metabolism signaling research
- Growth-hormone fragment structure-activity relationships
- Cartilage and chondrocyte biology (preclinical osteoarthritis models)
- Comparative pharmacology with full-length hGH and GH-axis peptides
- Non-receptor-mediated metabolic peptide research
Technical profile
- Net content
- 5 mg
- Molecular formula
- C78H123N23O23S2
- Molecular weight
- 1815.1 g/mol
- CAS
- 221231-10-3
- Sequence
- Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe (disulfide Cys7-Cys14)
For research use only. Not for human or veterinary consumption. Not intended to diagnose, treat, cure, or prevent any disease. Catalog availability restricted to verified licensed practitioners.
AOD-9604 is a synthetic peptide fragment derived from the C-terminal region of human growth hormone (hGH), corresponding to amino acids 176–191 in common nomenclature. Research literature describes stimulation of lipolysis and inhibition of lipogenesis with a more targeted profile than full-length GH.
